Host Response to Infection

Advancing Medicine with Actionable Diagnostics


Decoding the Host Response to Infection Requires Comprehensive, Accessible Solutions

Infection can sometimes present as a medical mystery, leaving clinicians with diagnostic uncertainty—unable to confirm the presence of an infection or its etiology. And critical decisions often need to be made based on incomplete or fragmented data from multiple tests, with each representing only a piece of the puzzle. Unraveling the complexities of infection requires the right combination of clinical biomarkers for deeper understanding of the patient condition.



What Constitutes an Infection?

It requires a pathogen, a susceptible host, and the manifestation of clinical disease.
Pathogen
0
A pathogen is introduced.
Host
0
The host’s immune system
reacts to the pathogen.
Clinical Disease
0
Symptoms of clinical
disease manifest.

The Host Response to Infection Tells a Powerful Story—And We’re Listening

Building upon our strong history of biomarker innovation, we are transforming the diagnostic landscape to help reduce diagnostic fragmentation, improve understanding of the host response to infection, and support overall patient health.


We are leading the way with novel clinical biomarkers and a comprehensive, cross-disciplinary portfolio—rethinking diagnostics to provide actionable insights into patient care.

accelerated intelligence
Advancing Diagnostic Biomarkers

We are delivering advanced diagnostic biomarkers & solutions to empower
clinicians to make faster, more informed decisions and determine the right treatment for their patients.

Leveraging Established, Novel, and Emerging Biomarkers

We are committed to identifying biomarkers that aid in the assessment
of the host response and underlying conditions.

Established Markers

White Blood Cell (WBC)

WBC levels may be either high or low during infection, among other medical conditions.

Procalcitonin (PCT)

PCT levels rise in the presence of a bacterial infection, and the levels are correlated with the severity of the infection.

C-Reactive Protein (CRP)

CRP levels tend to rise during inflammation or infection and fall during recovery, suggesting levels could be used to monitor infection and treatment.

Novel Markers

Monocyte Distribution Width (MDW)

MDW is a risk stratification tool that works as part of your ED’s existing CBC-Diff workflow to measure the risk of having sepsis or of developing sepsis within the next 12 hours.

Emerging Inflammatory Markers

Ferritin

Ferritin is a test often used to detect iron deficiency, but it is also a marker of inflammation in the body. As such, ferritin levels tend to rise when there is an underlying condition that can cause inflammation—such as infection.

Interleukin-6 (IL-6)

IL-6 is predominantly considered to be a pro-inflammatory cytokine, produced wherever there is inflammation—including during infection—but it has also been shown to play an anti-inflammatory role.

Powering the Testing You Need, When
and Where You Need It

Is it bacterial or viral? Make faster, more informed decisions with rapid, accurate host response information to differentiate
bacterial and viral infections and lower the chance of inappropriate patient management & antibiotic misuse.

 

Meet MeMed BV

 


adaptive collaboration
Partnering to Accelerate Clinical Research

We are restructuring the way we innovate by investing in and fostering new collaborative
partnerships to identify novel diagnostic biomarkers to advance infection management.

Collaborative Research

Through the Danaher Beacons program, we are investing in pioneering, world-renowned academic institutions to accelerate the development of innovative technologies for serious conditions like sepsis.

Partnering to Accelerate Clinical Research

Cepheid

Cepheid is dedicated to improving healthcare by pioneering molecular diagnostics that combine speed, accuracy, and flexibility.

Radiometer

Radiometer's products and solutions help diagnose and care for critically ill hospital patients by providing fast, accurate information on a variety of parameters.

Turn to the Danaher Ecosystem

As a Danaher company, we are part of a unique family of businesses working together to make a greater impact than we could alone.
Get to know Danaher Diagnostics and discover how we are partnering to advance global understanding of host immune responses.

 


Improved Efficiency Icon
Improved Diagnostic Efficiency

We are bringing together host response expertise across laboratory disciplines to create comprehensive solutions for
complex clinical challenges, ensuring precise execution on timing and results.

Your Trusted Partner for 80+ Years

Count on our decades of innovation and continuous improvement to help you support faster, more confident clinical decisions, streamline testing
across disciplines, and expedite patient care. From hematology, immunoassay, microbiology, and molecular solutions to laboratory automation
and clinical decision support, there’s much more to explore.

 

Innovative Biomarker Solutions We’re focused on the clinical biomarker innovations you need across disciplines.

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infectious-disease
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Learn how we’re designing our broad and expanding infectious disease portfolio to help you meet your challenges, sustain efficient workflows, and deliver actionable results.
2024-13678